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Anne Rowling Regenerative Neurology Clinic
Centre for Cognitive Ageing & Cognitive Epidemiology
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Euan MacDonald Centre for MND Research

In The News 2017

January
2017
Schizophrenia study reveals genetic clue to depression causes
Researchers at the University of Edinburgh used samples provided by Generation Scotland - a bank of human tissue from volunteers - to look for genetic causes of depression, as part of an initiative called STRADL (stratifying resilience and depression longitudinally). Results show that a specific type of depression may affect people who are genetically at risk of schizophrenia. The study was also covered this morning on three seperate radio shows - The World Service, BBC Scotland breakfast radio and Talk Radio.
original article (01nov16)
BBC News (09jan17)
New Wellcome Trust Investigator for Edinburgh Neuroscience
Prof. Mike Cousin (Centre for Integrative Physiology and Muir Maxwell Epilepsy Centre) has been awarded an Investigator Award in Science by the Wellcome Trust. This was a 5 year award totalling £1.78 million which will determine the role of activity-dependent bulk endocytosis in mammalian physiology at the molecular, synaptic, circuit and behavioural level. Congratulations Mike!

In The News 2016

December
2016
Cognitive Assessments in the detection of Alzheimer's disease
Dr. Mario Parra Rodriguez (Heriot Watt University & Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh) is developing assessments to help seperate the cognitive decline of people with Alzheimer's disease from changes associated with normal ageing. Researchers at Heriot Watt University, in collaboration with the University of Edinburgh, are also investigating training packages to help people wiith Alzheimer's disease by using computer science to create a virtual environment to stimulate people's own homes. Read more about these studies in the articles below...
Care and Cure
Alzheimer's Society magazine
Impact of ageing on brain connections
Research carried out by the Centre for Cognitive Ageing and Cognitive Epidemiology shows that brain connections playing a key role in complex thinking skills are not well preserved in later life. Findings show, however, that connections supporting functions such as movement and hearing are relatively well preserved in later life.
original article (15dec16)
CCACE video explanation
Science Daily (15dec16)
Gut cells may explain vCJD susceptibility
Professor Neil Mabbott (The Rosin Institute) and colleagues have discovered why some people appear more susceptible to infection by prion proteins, which cause variant Creutzfeldt-Jakob disease (vCJD) in people and bovine spongiform encephalopathy (BSE) in cows. Their study, in mice, found that M cells (specialised cells important for transporting material across the lining of the GI tract) are used by prions to infect the gut and the greater the number of M cells, the greater the infection by prions. Since young people tend to have more M cells than older people, this might explain why most vCJD cases were in young people.
ScienceDaily article (14dec16)
Original article in PLOS Pathogens
Spinal Muscular Atrophy clinical trial editorial
Professor Tom Gillingwater (Centre for Integrative Physiology and Euan MacDonald Centre for MND Research) has written an editorial in The Lancet discussing the publication of a clinical trial for SMA (a mono-genetic neurodegenerative disorder which affects babies and is often known as floppy baby syndrome). This trial has demonstrated the safety and feasibility of delivering a modified antisense drug, nusinersen, designed to alter splicing of SMN2 pre-mRNA and increased SMN protein concentrations. This bodes well for future trials for treatments for this devastating condition.
The Lancet Editorial (06dec16)

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