Siddharthan Chandran

Siddharthan Chandran

MacDonald Chair of Neurology
0131 242 9519 (PA)
Organisation Associations 
Centre for Clinical Brain Sciences
Euan MacDonald Centre for Motor Neurone Disease Research
MRC Centre for Regenerative Medicine
Anne Rowling Regenerative Neurology Clinic
Edinburgh Neuroscience
Edinburgh Imaging Facilities
Research in a nutshell 

Neurodegenerative diseases affect cells in the nervous system called neurons. Twenty million people worldwide are diagnosed with a neurodegenerative disease each year, and at present they are all progressive and incurable.

The Chandran group links clinical activity with laboratory research into two such conditions: multiple sclerosis and motor neurone disease. Measuring disease course and treatment outcomes through disease bio-registers builds an increasingly accurate clinical picture.

In parallel, studies in the lab —including using human stem cells—focus on understanding what is going wrong in the neurons and supporting cells called glia. Bringing these two strands together, the group aims to develop novel regenerative therapies and bring them to early-phase clinical trials.