New study reveals how neurones control astrocytes

New study reveals how neurones control astrocytes

 

Wednesday, 10 May, 2017

Professor Giles Hardingham (Centre for Integrative Physiology and Associate Director for the new UK Dementia Research Institute at University of Edinburgh) and colleagues have published a study that uncovers how neurones influence astocyte function. Although it has been known that neurones and glia interact, the mechanim by which neurone -to-astrocyte signalling occurs is not well understood. This study, published in Nature Communications, used a system of co-culturing neurones and astrocytes from different, but closely-related, species to uncover extensive gene expression changes in the astrocytes. They found that neurones, and neuronal activity, induced expression of a wide range of genes in the astocytes and that these were genes that show age dependant decline in humans.

This work was profiled by the UK Dementia Research Institute