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Three collaborative pilot project grants have been awarded to foster trans-Atlantic cooperation
Researchers at the University of Edinburgh (Dr Barry McColl, Laura McCulloch and colleagues - Roslin Institute) have been awarded a £1.3M grant from the Medical Research Council (MRC) to study the immunological mechanisms related to B cell function that are disrupted after stroke and could contribute to stroke-associated infection (SAI).
A new study, published in Nature and jointly led by Professor Charles ffrench-Constant, Professor Anna Williams (MRC Centre for Regenerative Medicine, University of Edinburgh) and Gonçalo Castelo-Branco (Karolinska Institutet, Stockholm, Sweden) offers fresh insights into the types of cells found in the brains of people with multiple sclerosis that could help develop improved therapies. The study focused on oligodendrocytes - cells in the brain that help to repair damage to nerve cells caused by the disease. Researchers identified various types oligodendrocytes and found that people with MS have different types of oligodendrocytes than healthy people. These findings could shed new light on how the disease progresses and could also help scientists develop treatments. The study is published in Nature. It was funded by the UK MS Society, the European Union and the European Research Council, The European Committee for Treatment and Research of Multiple Sclerosis and the Wellcome Trust, among others.
Dr Chris Henstridge and Professor Tara Spires-Jones (both Centre for Discovery Brain Sciences) and colleagues have published a study which sheds light on how motor neurone disease (MND) affects the processes within the brain.
Dr Thomas Becker and colleagues in the Centre for Neuroregeneration have used the regenerative capacity of zebrafish to uncover key mechanisms in the regrowth of spinal cord neurones following damage.They found that collagen 12 is produced by fibroblasts and this changes the structure of the support matrix which surrounds the nerve fibres, enabling regrowth across the wound site.