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Professor Seth Grant (Centre for Clinical Brain Sciences) and colleagues have published findings suggesting the existence of a genetic programme that controls the way our brain changes throughout life.
Professor Seth Grant (Centre for Clinical Brain Sciences), Professor Douglas Armstrong (Informatics) and colleagues in the Centre Clincial Brain Sciences and at the Lilly Research Centre (Surrey), have analysed the molecules produced at synapses in various parts of the brain and found that varying compositions correspond to brain functions. The team found that this map can now bridge the gap between genetic studies and findings from brain imaging, shedding light on why smokers might develop a habit.
Professor Adrian Bird and colleagues (all School of Biological Sciences), in collaboration with Dr. Stuart Cobb and colleagues (formerly University of Glasgow, now Centre for Discovery Brain Sciences), have recently written a report for Nature on their research into Rett Syndrome.
Research led by Dr Martha Koerner (School of Biological Sciences) has resulted in fresh insights into the rare genetic disorder known as MeCP2 duplication syndrome, which mainly affects boys and leads to severe intellectual disability, seizures and impaired motor function, that could pave the way for new treatments for the condition.
Dr Matthew Lyst, Prof Adrian Bird and colleagues (School of Biological Sciences) have published a study that examines the structure and interactions of proteins whose genes are mutated in Rett Syndrome, a disease that results in intellectual disability in girls.
Professor Giles Hardingham (Centre for Integrative Physiology and Associate Director for the new UK Dementia Research Institute at University of Edinburgh) and colleagues have published a study that uncovers how neurones influence astocyte function.
Dr Thomas Becker and colleagues in the Centre for Neuroregeneration have used the regenerative capacity of zebrafish to uncover key mechanisms in the regrowth of spinal cord neurones following damage.They found that collagen 12 is produced by fibroblasts and this changes the structure of the support matrix which surrounds the nerve fibres, enabling regrowth across the wound site.