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Congratulations to Professor Seth Grant who has been selected as the recipient of the 2019 International Behavioural and Neural Genetics Society (IBANGS) Distinguished Investigator Award.
Dr Christos Gkogkas and colleagues in the Patrick Wild Centre have found that a commonly used diabetes drug, Metformin, could help people with a common inherited form of autism (fragile X syndrome).
Dr Pleasantine Mill (MRC Human Genetics Unit) has identified a gene, involved in brain development, which can lead to disability and death in infants.
Professor Ian Deary and Dr David Hill (both centre for Cognitive Ageing & Cognitive Epidemiology) and colleagues from University of Southampton and Harvard have identified over 500 genes linked to intelligence in the largest study of its kind.
New study led by Professor Mick Watson indicates that advanced technologies which read long strings of DNA can produce flawed data that could affect genetic studies. This project examined three previous studies reporting human genome sequences from long-read technologies. They found that the data contained thousands of errors even after corrective software was used, indicating that the data produced by these technologies should be interpreted with caution, as it may create problems for analysing genetic information from people and animals.
Professor Seth Grant (Centre for Clinical Brain Sciences), Professor Douglas Armstrong (Informatics) and colleagues in the Centre Clincial Brain Sciences and at the Lilly Research Centre (Surrey), have analysed the molecules produced at synapses in various parts of the brain and found that varying compositions correspond to brain functions. The team found that this map can now bridge the gap between genetic studies and findings from brain imaging, shedding light on why smokers might develop a habit.
Research led by Dr Martha Koerner (School of Biological Sciences) has resulted in fresh insights into the rare genetic disorder known as MeCP2 duplication syndrome, which mainly affects boys and leads to severe intellectual disability, seizures and impaired motor function, that could pave the way for new treatments for the condition.
Professor Andrew McIntosh (Centre for Clinical Brain Sciences), Professor Ian Deary (Centre for Cognitive Ageing and Epidemiology), Dr Michelle Luciano (Centre for Cognitive Ageing and Epidemiology) and colleagues (University of Edinburgh and King's College London) have published results from a study suggesting that people affected by depression may have genes associated with anxiety, worry and low mood. The DNA of over 300,000 people was analysed and many genes were found to link to neuroticism – characterised by feelings of anxiety, worry and guilt. The genes are also linked to depression. The findings help shed light on the causes of depression – which affects one in five people – and could provide information to help better diagnosis and treatment for individuals, scientists say.
Prof Andrew McIntosh (Centre for Clinical Brain Sciences - Psychiatry) and colleagues have publis
Staying Sharp is a new ‘one-stop-shop’ on the Age UK website, developed in partnership with the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) at the University of Edinburgh, where you can find out what you need to know about thinking skills in later life.