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Professor Seth Grant (Centre for Clinical Brain Sciences) and colleagues have published findings suggesting the existence of a genetic programme that controls the way our brain changes throughout life.
Dr Christos Gkogkas and colleagues (Centre for Discovery Brain Sciences, and Patrick Wild Centre) have published a study that may shed light on why a certain category of antidepressant drugs stop working in some people.
Professor Seth Grant (Centre for Clinical Brain Sciences), Professor Douglas Armstrong (Informatics) and colleagues in the Centre Clincial Brain Sciences and at the Lilly Research Centre (Surrey), have analysed the molecules produced at synapses in various parts of the brain and found that varying compositions correspond to brain functions. The team found that this map can now bridge the gap between genetic studies and findings from brain imaging, shedding light on why smokers might develop a habit.
Researchers at the University of Edinburgh (Dr Barry McColl, Laura McCulloch and colleagues - Roslin Institute) have been awarded a £1.3M grant from the Medical Research Council (MRC) to study the immunological mechanisms related to B cell function that are disrupted after stroke and could contribute to stroke-associated infection (SAI).
Professor Adrian Bird and colleagues (all School of Biological Sciences), in collaboration with Dr. Stuart Cobb and colleagues (formerly University of Glasgow, now Centre for Discovery Brain Sciences), have recently written a report for Nature on their research into Rett Syndrome.
Many types of neuromuscular disease, such as spinal muscular atrophy (SMA) and Charcot-Marie-Toot
Research led by Dr Martha Koerner (School of Biological Sciences) has resulted in fresh insights into the rare genetic disorder known as MeCP2 duplication syndrome, which mainly affects boys and leads to severe intellectual disability, seizures and impaired motor function, that could pave the way for new treatments for the condition.
Dr Matthew Lyst, Prof Adrian Bird and colleagues (School of Biological Sciences) have published a study that examines the structure and interactions of proteins whose genes are mutated in Rett Syndrome, a disease that results in intellectual disability in girls.
Professor Giles Hardingham (Centre for Integrative Physiology and Associate Director for the new UK Dementia Research Institute at University of Edinburgh) and colleagues have published a study that uncovers how neurones influence astocyte function.
Prof. Mike Cousin (Centre for Integrative Physiology and Muir Maxwell Epilepsy Centre) has been awarded an Investigator Award in Science by the Wellcome Trust.