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New study led by Professor Mick Watson indicates that advanced technologies which read long strings of DNA can produce flawed data that could affect genetic studies. This project examined three previous studies reporting human genome sequences from long-read technologies. They found that the data contained thousands of errors even after corrective software was used, indicating that the data produced by these technologies should be interpreted with caution, as it may create problems for analysing genetic information from people and animals.
Professor Seth Grant (Centre for Clinical Brain Sciences), Professor Douglas Armstrong (Informatics) and colleagues in the Centre Clincial Brain Sciences and at the Lilly Research Centre (Surrey), have analysed the molecules produced at synapses in various parts of the brain and found that varying compositions correspond to brain functions. The team found that this map can now bridge the gap between genetic studies and findings from brain imaging, shedding light on why smokers might develop a habit.
Professor Tom GIllingwater (Centre for Integrative Physiology, and Euan MacDonald Centre for MND Research) has been awarded a grant from MND (Motor Neurone Disease) Scotland for the project titled: 'Identifying and targeting neuroprotective pathways in motor neurons'. Congratulations Tom!
Professor Adrian Bird and colleagues (all School of Biological Sciences), in collaboration with Dr. Stuart Cobb and colleagues (formerly University of Glasgow, now Centre for Discovery Brain Sciences), have recently written a report for Nature on their research into Rett Syndrome.
Research led by Dr Martha Koerner (School of Biological Sciences) has resulted in fresh insights into the rare genetic disorder known as MeCP2 duplication syndrome, which mainly affects boys and leads to severe intellectual disability, seizures and impaired motor function, that could pave the way for new treatments for the condition.
Dr Matthew Lyst, Prof Adrian Bird and colleagues (School of Biological Sciences) have published a study that examines the structure and interactions of proteins whose genes are mutated in Rett Syndrome, a disease that results in intellectual disability in girls.
Professor Giles Hardingham (Centre for Integrative Physiology and Associate Director for the new UK Dementia Research Institute at University of Edinburgh) and colleagues have published a study that uncovers how neurones influence astocyte function.
Professor Andrew McIntosh (Centre for Clinical Brain Sciences), Professor Ian Deary (Centre for Cognitive Ageing and Epidemiology), Dr Michelle Luciano (Centre for Cognitive Ageing and Epidemiology) and colleagues (University of Edinburgh and King's College London) have published results from a study suggesting that people affected by depression may have genes associated with anxiety, worry and low mood. The DNA of over 300,000 people was analysed and many genes were found to link to neuroticism – characterised by feelings of anxiety, worry and guilt. The genes are also linked to depression. The findings help shed light on the causes of depression – which affects one in five people – and could provide information to help better diagnosis and treatment for individuals, scientists say.
Prof Andrew McIntosh (Centre for Clinical Brain Sciences - Psychiatry) and colleagues have publis
The Scottish Genomes Partnership has signed up its first recruits in a study which will sequence the entire genome of 1000 people, including 330 who have rare diseases, which include conditions such as muscular dystrophies, rare forms of intellectual disability and rare inherited neurological problems.