Edinburgh α-Synuclein Workshop
13.30 Tilo Kunath – MRC Centre for Regenerative Medicine
“Introduction to α-synuclein human iPSC and rat models”
13.45 Yixi Chen – Synthetic Biology PhD student with Tilo Kunath
“Engineering synucleinopathy-resistant neurons with CRISPR/Cas9 nickase”
13.55 Stephen West – Tissue Repair PhD student with Tilo Kunath
“Phenotyping a CRISPR-engineered G51D α-synuclein rat model”
14.05 Bhanu Singh – Post-doctoral fellow with Prof Cait MacPhee
“Amyloid formation by α-synuclein in absence of air-water interface in a confined volume”
14.20 Mathew Horrocks – Lecturer in Chemistry and Dementia Research Institute
“Designer fluorescent peptides for the super-resolution imaging of protein aggregates”
14.35 Joanna Koszela – Post-doctoral fellow with Prof Manfred Auer
“Real-time tracking of ubiquitination cascades using a confocal on-bead assay”
14.50 Irene Pérez Pi – Post-doctoral fellow with Prof Manfred Auer
“A novel bead-based assay for early α-synuclein oligomerization”
15.05 Coffee break and discussions
15.45 Suneil Kalia – Division of Neurosurgery, Toronto Western Hospital
“Chaperoning Parkin mediated mitophagy”
16.15 Lorraine Kalia – Krembil Research Institute, Toronto
“Parkinsonism due to A53E α-synuclein: clinical, genetic, epigenetic, and biochemical features”
16.45 Q&A